Multidisciplonary approach to methotrexate intoxication in pediatrics

Abstract

Methotrexate (MTX) is an immunosuppressive drug and folic acid inhibitor that decreases the levels of tetrahydrofolate in cells, whose mechanism of action is based on blocking the enzymes dihydrofolate reductase and thymidylate synthetase, which play a key role in the synthesis of nucleic acids. However, chronic use of this medication brings with it the probability of developing severe systemic toxicity, mostly pulmonary and hepatic, concomitant with infectious processes. This article reports the case of a patient who was being treated with Methotrexate due to a diagnosis of Juvenile Rheumatoid Arthritis, who presented signs of severe toxicity and was treated at the Erasmo Meoz University Hospital with a response. favorable. Early recognition of the adverse effects of the drug and its clinical characterization is important, therefore, it is estimated that the immediate suspension of medication and adequate treatment are factors that contribute to comprehensive management and reduction of morbidity.