Therapeutic approach to myeloproliferative neoplasms in pregnant patients: clinical case

Abstract

Essential thrombocythemia is a Philadelphia-negative chronic myeloproliferative neoplasm, characterized by thrombocytosis and megakaryocytic hyperplasia of the bone marrow; Therefore, it is a benign condition that recovers completely in the postpartum period. Although the cause is not fully understood, pregnancy-related hemodilution and increased platelet consumption are thought to play an important contributing role. Methodology. Descriptive-retrospective review of a case of a patient with MPN and pregnancy, evaluated in a Colombian provincial hospital of medium complexity, between January 2020 and May 2023. Results. Female at 27 weeks pregnant G3C2V1M1, who presented with gestational thrombocytosis during the third trimester of her three consecutive pregnancies, followed by complete recovery after each pregnancy. We rule out other sinister and life-threatening causes of thrombocytosis in pregnancy. Conclusion. The treatment and management of essential thrombocytosis requires an interprofessional team approach, involving physicians, nursing, and pharmacy staff, working together to achieve optimal patient outcomes.