Clinical characterization of SARS-CoV-2 infection in pregnancy women and newborns attended at the E.S.E Hospital Universitario Erasmo Meoz Cúcuta in the period 2020-2021
DOI:
https://doi.org/10.24054/cbs.v1i1.2517Keywords:
Pregnancy, SARS-COV-2, COVID-19, Pregnancy Complications, newbornAbstract
Introduction: SARS-CoV-2 infection has become a public health emergency. Knowledge about its impact on pregnant women and neonates continues to be controversial. It is considered that the physiological changes of pregnancy increase the risk of developing worse outcomes, being associated with greater morbidity and mortality. Objective: To know the clinical characteristics of SARS-CoV-2 infection in pregnant women and newborns treated at the Erasmo Meoz University Hospital
(HUEM), Cúcuta, 2020-2021. Methods: Descriptive, cross-sectional, and retrospective study. Pregnant women with SARS-CoV-2 infection who attended the HUEM between 2020-2021 were included. Sociodemographic data, history, clinical and paraclinical results, and newborn data at birth were collected. The association of age, BMI, comorbidities, and paraclinical findings with the requirement of supplemental oxygen and admission to the ICU was analyzed. Statistical analysis: Chi-square. Significance p<0.05. Results: 75 pregnant women with SARS-COV2 infection and 53 neonates were included. The most frequent symptoms were cough (56%), fever (48%) and general malaise (44%). The main analytical findings were lymphopenia (28%), PCR, and elevated D-dimer (72 and 78.7%). 17.3% were admitted to the ICU. The most common outcomes were prematurity (22.7%) and low birth weight (32.1%). A significant association was observed between age and oxygen requirement, and between elevated D-Dimer and Ferritin with admission to the ICU. Conclusions: Pregnant women with SARS-CoV-2 present symptoms similar to those of the general population. The most frequent laboratory findings are increased D-dimer, PCR, and lymphopenia, similar to the general population. However, it is associated with an increase in the need for supplemental oxygen and ICU. An increase in premature deliveries, cesarean sections, and low birth weight was determined. These findings could improve the follow-up of pregnant women with SARS-CoV-2, although they must be interpreted carefully due to the small number of cases. Additional research with a larger population is required, also research on vertical transmission.
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References
Peña-López, B. O., & Rincón-Orozco, B. (2020). Generalidades de la Pandemia por COVID-19 y su asociación genética con el virus del SARS. Revista de la Universidad Industrial de Santander Salud, 52(2), 83–86. https://doi.org/10.18273/revsal.v52n2-2020001 DOI: https://doi.org/10.18273/revsal.v52n2-2020001
Liu, H., Wang, L.-L., Zhao, S.-J., Kwak-Kim, J., Mor, G., & Liao, A.-H. (2020). Why are pregnant women susceptible to COVID-19? An immunological viewpoint. Journal of Reproductive Immunology, 139(103122), 103122. https://doi.org/10.1016/j.jri.2020.103122 DOI: https://doi.org/10.1016/j.jri.2020.103122
Jafari, M., Pormohammad, A., Sheikh Neshin, S. A., Ghorbani, S., Bose, D., Alimohammadi, S., Basirjafari, S., Mohammadi, M., Rasmussen-Ivey, C., Razizadeh, M. H., Nouri-Vaskeh, M., & Zarei, M. (2021). Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis. Reviews in medical virology, 31(5), 1–16. https://doi.org/10.1002/rmv.220 DOI: https://doi.org/10.1002/rmv.2208
Di Toro, F., Gjoka, M., Di Lorenzo, G., De Santo, D., De Seta, F., Maso, G., Risso, F. M., Romano, F., Wiesenfeld, U., Levi-D'Ancona, R., Ronfani, L., & Ricci, G. (2021). Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis. Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 27(1), 36–46. https://doi.org/10.1016/j.cmi.2020.10.007 DOI: https://doi.org/10.1016/j.cmi.2020.10.007
Knight, M., Bunch, K., Vousden, N., Morris, E., Simpson, N., Gale, C., O’Brien, P., Quigley, M., Brocklehurst, P., & Kurinczuk, J. J. (2020). Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population-based cohort study. BMJ (Clinical Research Ed.), 369, m2107. https://doi.org/10.1136/bmj.m2107 DOI: https://doi.org/10.1136/bmj.m2107
Allotey, J., Stallings, E., Bonet, M., Yap, M., Chatterjee, S., Kew, T., Debenham, L., Llavall, A. C., Dixit, A., Zhou, D., Balaji, R., Lee, S. I., Qiu, X., Yuan, M., Coomar, D., Sheikh, J., Lawson, H., Ansari, K., van Wely, M., van Leeuwen, E. (2020). Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ (Clinical research ed.), 370, m3320. https://doi.org/10.1136/bmj.m3320 DOI: https://doi.org/10.1097/01.aoa.0000744128.44930.48
Vouga, M., Favre, G., Martinez-Perez, O., Pomar, L., Acebal, L. F., Abascal-Saiz, A., Hernandez, M. R. V., Hcini, N., Lambert, V., Carles, G., Sichitiu, J., Salomon, L., Stirnemann, J., Ville, Y., de Tejada, B. M., Goncé, A., Hawkins-Villarreal, A., Castillo, K., Solsona, E. G., Trigo, L., … Panchaud, A. (2021). Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Scientific reports, 11(1), 13898. https://doi.org/10.1038/s41598-021-92357-y DOI: https://doi.org/10.1038/s41598-021-92357-y
Breslin, N., Baptiste, C., Gyamfi-Bannerman, C., Miller, R., Martinez, R., Bernstein, K., Ring, L., Landau, R., Purisch, S., Friedman, A. M., Fuchs, K., Sutton, D., Andrikopoulou, M., Rupley, D., Sheen, J. J., Aubey, J., Zork, N., Moroz, L., Mourad, M., Wapner, R., … Goffman, D. (2020). Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. American journal of obstetrics & gynecology MFM, 2(2), 100118.https://doi.org/10.1016/j.ajogmf.2020.100118 DOI: https://doi.org/10.1016/j.ajogmf.2020.100118
Pereira, A., Cruz-Melguizo, S., Adrien, M., Fuentes, L., Marin, E., & Perez-Medina, T. (2020). Clinical course of coronavirus disease-2019 in pregnancy. Acta obstetricia et gynecologica Scandinavica, 99(7), 839–847. https://doi.org/10.1111/aogs.1392 DOI: https://doi.org/10.1111/aogs.13921
Zhang, C., Chu, H., Pei, Y. V., & Zhang, J. (2021). Laboratory Effects of COVID-19 Infection in Pregnant Women and Their Newborns: A Systematic Review and Meta-Analysis. Frontiers in global women's health, 2,647072.https://doi.org/10.3389/fgwh.2021.647072 DOI: https://doi.org/10.3389/fgwh.2021.647072
Mark, E. G., McAleese, S., Golden, W. C., Gilmore, M. M., Sick-Samuels, A., Curless, M. S., Nogee, L. M., Milstone, A. M., & Johnson, J. (2021). Coronavirus Disease 2019 in Pregnancy and Outcomes Among Pregnant Women and Neonates: A Literature Review. The Pediatric infectious disease journal, 40(5), 473–478. https://doi.org/10.1097/INF.0000000000003102 DOI: https://doi.org/10.1097/INF.0000000000003102
Gálvez-Vengoechea ML, Arreaza-Graterol M, Rodríguez-Ortiz JA. (2009). Mortalidad materna de pacientes atendidas en la UCI del Hospital Simón Bolívar, Bogotá (Colombia). Revista Colombiana de Obstetricia y Ginecología, 60(2), 152-158. http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74342009000200005&lng=en&tlng=es DOI: https://doi.org/10.18597/rcog.340
Boletín Técnico Estadísticas Vitales (EEVV). Nacimientos en Colombia.DANE.(2018).https://www.dane.gov.co/files/investigaciones/poblacion/bt_estadisticasvitales_nacimientos_IIItrim_2021pr.pdf
Abedzadeh-Kalahroudi, M., Sehat, M., Vahedpour, Z., Talebian, P., & Haghighi, A. (2021). Clinical and obstetric characteristics of pregnant women with Covid-19: A case series study on 26 patients. Taiwanese journal of obstetrics & gynecology, 60(3), 458–462. https://doi.org/10.1016/j.tjog.2021.03.012 DOI: https://doi.org/10.1016/j.tjog.2021.03.012
Análisis de situación de salud Colombia (2015). Ministerio de Salud. https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VS/ED/PSP/asis-2015.pdf
Shakaroun, D. A., Lazar, M. H., Horowitz, J. C., & Jennings, J. H. (2023). Serum Ferritin as a Predictor of Outcomes in Hospitalized Patients with Covid-19 Pneumonia. Journal of intensive care medicine, 38(1), 21–26. https://doi.org/10.1177/08850666221113252 DOI: https://doi.org/10.1177/08850666221113252
Arslan, B., Bicer, I. G., Sahin, T., Vay, M., Dilek, O., & Destegul, E. (2022). Clinical characteristics and hematological parameters associated with disease severity in COVID-19 positive pregnant women undergoing cesarean section: A single-center experience. The journal of obstetrics and gynaecology research, 48(2), 402–410. https://doi.org/10.1111/jog.15108. DOI: https://doi.org/10.1111/jog.15108
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