Bronchopleural fistula secondary to spontaneous pneumothorax due to bullous disease: case report
DOI:
https://doi.org/10.24054/cbs.v3i4.4183Keywords:
bullous lung disease, spontaneous pneumothorax, bronchopleural fistula, video-assisted thoracoscopic surgery, COPDAbstract
Bullous lung disease is a variant of emphysema characterized by the formation of air cavities larger than 1 cm, primarily associated with COPD and chronic smoking. Its complications include spontaneous pneumothorax, hemoptysis, bulla infection, and bronchopleural fistula, the latter of which is difficult to manage clinically and carries a high morbidity and mortality rate. Spontaneous pneumothorax secondary to bullous disease can be complicated by bronchopleural fistula, a rare condition outside of surgery. Persistent air leak limits conservative management and requires consideration of surgery. Video-assisted thoracoscopy and limited lung resections are effective and safe options, improving prognosis and respiratory function in selected patients. Furthermore, bronchopleural fistula secondary to spontaneous pneumothorax due to bullous disease is a rare but serious complication. Timely diagnosis and adequate surgical approach are crucial for clinical recovery and reduced morbidity and mortality in these patients. We present the case of a 63-year-old male patient with a history of COPD and chronic smoking who was admitted with a left pneumothorax initially managed with closed thoracostomy. He presented with a persistent air leak secondary to severe bullous emphysema. Due to the lack of resolution with conservative management, surgery was performed, revealing a ruptured apical bulla with a bronchopleural fistula, fibrinopurulent pleural effusion, and lung entrapment. A non-anatomical segmentectomy was performed with closure of the fistula. The postoperative outcome was favorable, and the patient was discharged on the fourth day without complications.
Downloads
References
Gibran MA, Khairsyaf O, Afriani A. Bullous Lung Disease (BLD): A Narrative Literature Review. Biosc Med. 2023;8(3):4159–68. doi:10.37275/bsm.v8i3.946
Siddiqui NA, Sankari A, Mansour MK, et al. Bullous Emphysema. [Updated 2025 Apr 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK537243/
Morán-Mariños C, Vidal-Ruiz M, Llanos-Tejada F, Chavez-Huamani A, Salas-Lopez J, Villanueva-Villegas R, et al. Bullous lung disease due to pulmonary tuberculosis: A rare case complicated with tension pneumothorax and bronchopleural fistula. Ther Adv Pulm Crit Care Med. 2024;18:1–5. doi:10.1177/29768675241249652
El Husseini K, Flament T, Laroumagne S, Basille D, Le Brun M, Noël-Savina E, et al. Mapping bullous emphysema with lung ultrasound: A prospective multicentre study. Respirology. 2025;30(7):633–43.
Bisconti M, De Palma A, Pacifici R, Rotolo MC, Pichini S, Brascia D, Trabucco X, Pellegrini M, Carrozzi L, Pistelli F, Marulli G. Spontaneous pneumothorax secondary to bullous lung emphysema positive for cannabinoids upon toxicological examination. J Clin Med. 2023;12(15):4956. doi:10.3390/jcm12154956
Han Y, Sun Y, Zhang M, Yang Y. A case of bullous lung disease complicated with pulmonary infection and respiratory failure. Ther Adv Respir Dis. 2024; 18:29768675241249652. doi:10.1177/29768675241249652
Gurung I, Ghassemzadeh S. Spontaneous Pneumothorax. [Updated 2025 Jul 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-https://www.ncbi.nlm.nih.gov/sites/books/NBK459302/
Duchman B, Cheng GZ. Management of pneumothorax and persistent air leak—a narrative review. AME Med J. 2024;9:23. doi:10.21037/amj-23-168
Saini N, Nar A, Jabbal HS, Mishra A, Bains MS. Video-assisted thoracoscopic surgery (VATS) for spontaneous pneumothorax and emphysematous bullous lung disease: a study from Northern India. Cureus. 2022;14(6):e25769. doi:10.7759/cureus.25769
Grotberg JC, Hyzy RC. Bronchopleural fistula in the mechanically ventilated patient: a concise review. Crit Care Med. 2021;49(2):292–301. doi:10.1097/CCM.0000000000004771
Clark JM, Cooke DT, Brown LM. Management of complications after lung resection: Prolonged air leak and bronchopleural fistula. Thorac Surg Clin. 2020;30(3):347–58. http://dx.doi.org/10.1016/j.thorsurg.2020.04.008
Zhao P. Progress report on interventional treatment for bronchopleural fistula. Front Med [Internet]. 2023 [cited 2025 Aug 25]. https://doi.org/10.1155/2023/8615055
Roberts ME, Neville E, Berrisford RG, Antunes G, Ali NJ, et al. British Thoracic Society guideline for pleural disease. Thorax. 2023 Nov;78(11):1143–56. doi:10.1136/thorax-2023-220304
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Basic Health sciencies journal

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.