ABNORMAL P53 DEGRADATION AND APOPTOSIS INDUCTION IN P53-MDM2 NETWORK USING PINNING CONTROL STRATEGY
DOI:
https://doi.org/10.24054/rcta.v2i32.101Palabras clave:
Redes de regulación genética, redes complejas, control tipo PIN, p53, Mdm2Resumen
Este artículo presenta el control tipo “PIN” para regular la actividad de la red p53-Mdm2. Esta red considera la degradación de p53 mediada por el incremento de Mdm2, el cual perturba la respuesta de estrés normal de p53. El modelo considera tres proteínas: p53, Mdm2 y ARF. p53 es regulado a través de un ciclo de retroalimentación que involucra su gen objetivo Mdm2 y un regulador indirecto ARF. Se presentan dos escenarios. Para el primer escenario, la red responde a un incremento de Mdm2 y una baja regulación de p53 sin ninguna entrada externa; luego, en el segundo escenario apoptosis es inducido por el control tipo “PIN”. El comportamiento dinámico de la red y la efectividad del controlador propuesto son ilustrados vía simulaciones.
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