Clinical perspectives in a singular case of chest wall liposarcoma: diagnosis and therapeutic strategies
DOI:
https://doi.org/10.24054/cbs.v2i2.2961Keywords:
Liposarcoma, Well-differentiated liposarcoma, Atypical Lipomatous TumorAbstract
Liposarcomas (LPS) are a type of cancer that develops in soft tissues and is characterized by deriving from fat cells. They are divided into two subtypes: well-differentiated (WDLPS) and dedifferentiated (DDLPS), both known for their resistance to conventional treatments. The case of a 57-year-old woman with a medical history of obesity and disc herniation is presented. She experienced a progressive increase in the size of a mass in her left hemithorax, accompanied by dyspnea and chest pain. Diagnostic evaluation, including ultrasound, chest tomography, and magnetic resonance imaging, was essential for appropriate therapeutic decisions. The patient underwent successful surgery to remove the mass, with subsequent confirmation of the diagnosis of well-differentiated liposarcoma through pathological analysis. This clinical case emphasizes surgery's crucial role in treating localized liposarcomas, aiming for complete resection to improve the patient's quality of life. The variability in response to conventional treatments highlights the importance of individually evaluating the molecular profile of each case, and long-term follow-up is essential to assess treatment effectiveness and patient prognosis. The need for further research to expand our knowledge and improve the management of these tumors is emphasized.
Downloads
References
Thway, Khin. “Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.” Seminars in diagnostic pathology vol. 36,2 (2019): 112-121. doi:10.1053/j.semdp.2019.02.006 DOI: https://doi.org/10.1053/j.semdp.2019.02.006
Lee, Alex Thomas John et al. “Clinical and Molecular Spectrum of Liposarcoma.” Journal of clinical oncology: official journal of the American Society of Clinical Oncology vol. 36,2 (2018): 151-159. doi:10.1200/JCO.2017.74.9598 DOI: https://doi.org/10.1200/JCO.2017.74.9598
Lawrence, W Jr et al. “Adult soft tissue sarcomas. A pattern of care survey of the American College of Surgeons.” Annals of surgery vol. 205,4 (1987): 349-59. doi:10.1097/00000658-198704000-00003 DOI: https://doi.org/10.1097/00000658-198704000-00003
Jo, Vickie Y, and Christopher D M Fletcher. “WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition.” Pathology vol. 46,2 (2014): 95-104. doi:10.1097/PAT.0000000000000050 DOI: https://doi.org/10.1097/PAT.0000000000000050
Singer, Samuel et al. “Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma.” Annals of surgery vol. 238,3 (2003): 358-70; discussion 370-1. Doi: 10.1097/01.sla.0000086542.11899.38 DOI: https://doi.org/10.1097/01.sla.0000086542.11899.38
ESMO/European Sarcoma Network Working Group. “Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.” Annals of oncology: official journal of the European Society for Medical Oncology vol. 25 Suppl 3 (2014): iii102-12. doi:10.1093/annonc/mdu254 DOI: https://doi.org/10.1093/annonc/mdu254
Mashima, Emi et al. “Recent Advancement in Atypical Lipomatous Tumor Research.” International journal of molecular sciences vol. 22,3 994. 20 Jan. 2021, doi:10.3390/ijms22030994 DOI: https://doi.org/10.3390/ijms22030994
Haddox, Candace L, and Richard F Riedel. “Recent advances in the understanding and management of liposarcoma.” Faculty reviews vol. 10 1. 4 Jan. 2021, doi:10.12703/r/10-1 DOI: https://doi.org/10.12703/r/10-1
Nishio, Jun, et al. "Biology and management of dedifferentiated liposarcoma: state of the art and perspectives." Journal of Clinical Medicine 10.15 (2021): 3230. DOI: https://doi.org/10.3390/jcm10153230
Gronchi, A., et al. "Soft tissue and visceral sarcomas: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up." Annals of Oncology 32.11 (2021): 1348-1365.
Muratori, Francesco, et al. "Liposarcoma: Clinico-pathological analysis, prognostic factors and survival in a series of 307 patients treated at a single institution." Journal of Orthopaedic Science 23.6 (2018): 1038-1044. DOI: https://doi.org/10.1016/j.jos.2018.06.008
Suarez-Kelly, Lorena P., Giacomo G. Baldi, and Alessandro Gronchi. "Pharmacotherapy for liposarcoma: current state of the art and emerging systemic treatments." Expert Opinion on Pharmacotherapy 20.12 (2019): 1503-1515. DOI: https://doi.org/10.1080/14656566.2019.1618271
Tyler, Robert, et al. "A review of retroperitoneal liposarcoma genomics." Cancer treatment reviews 86 (2020): 102013. DOI: https://doi.org/10.1016/j.ctrv.2020.102013
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Basic Health sciencies journal
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
