Impact of pulmonary vein isolation on left atrial contractile function in patients with paroxysmal atrial fibrillation: a prospective cohort analysis using strain echocardiography

Authors

DOI:

https://doi.org/10.24054/cbs.v3i2.4043

Keywords:

Paroxysmal atrial fibrillation, Left atrial strain, Pulmonary vein Isolation

Abstract

Objetive Assess left atrial (LA) contractile function in patients with paroxysmal (AF) using strain echocardiography before and after pulmonary vein isolation (PVI) and compare them with matched controls. Methods A prospective cohort study was conducted at the National Institute of Cardiology Ignacio Chavez from May 2021 to November 2022. Patients with paroxysmal AF underwent transthoracic echocardiography (TTE) assessing LA global strain and strain in the LA reservoir, conduit, and contraction phases strains before and after PVI. Echocardiographic parameters were compared prior to and after PVI, and against matched controls. Results 15 subjects with paroxysmal AF and 15 matched controls were analyzed. Post-PVI, subjects showed significant improvements in LA global and reservoir phase strains. Compared to controls, significant echocardiographic differences were noted pre-PVI, but not post-PVI. Conclusion PVI may enhance LA strain parameters in paroxysmal AF patients, aligning them with matched controls. This suggests PVI's potential restorative effect on atrial function. Further research is warranted to validate these observations.

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References

Brundel BJJM, Ai X, Hills MT, Kuipers MF, Lip GYH, de Groot NMS. Atrial fibrillation. Nat Rev Dis Primer. 2022;8(1):1-23. doi:10.1038/s41572-022-00347-9

Mares RG, Nistor DO, Golu MV. Usefulness of left atrial speckle-tracking echocardiography in patients with atrial fibrillation. Anatol J Cardiol. 2017;18(5):377-378. doi:10.14744/AnatolJCardiol.2017.8070

Cameli M, Mandoli GE, Loiacono F, Sparla S, Iardino E, Mondillo S. Left atrial strain: A useful index in atrial fibrillation. Int J Cardiol. 2016;220:208-213. doi:10.1016/j.ijcard.2016.06.197

Lee MKS, Murphy AJ. A high-salt diet promotes atherosclerosis by altering haematopoiesis. Nat Rev Cardiol. Published online April 24, 2023:1-2. doi:10.1038/s41569-023-00879-x

Yoon YE, Kim HJ, Kim SA, Kim SH, Park JH, Park KH, et al. Left atrial mechanical function and stiffness in patients with paroxysmal atrial fibrillation. J Cardiovasc Ultrasound. 2012;20(3):140-145. doi:10.4250/jcu.2012.20.3.140

Liao JN, Chao TF, Kuo JY, Sung KT, Tsai JP, Lo CI, et al. Global Left Atrial Longitudinal Strain Using 3-Beat Method Improves Risk Prediction of Stroke Over Conventional Echocardiography in Atrial Fibrillation. Circ Cardiovasc Imaging. 2020;13(8):e010287. doi:10.1161/CIRCIMAGING.119.010287

Olsen FJ, Biering-Sørensen SR, Reimer Jensen AM, Schnohr P, Jensen GB, Svendsen JH, et al. Global longitudinal strain predicts atrial fibrillation in individuals without hypertension: A Community-based cohort study. Clin Res Cardiol. 2021;110(11):1801-1810. doi:10.1007/s00392-021-01921-z

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344-349. doi:10.1016/j.jclinepi.2007.11.008

Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373-498. doi:10.1093/eurheartj/ehaa612

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr. 2015;28(1):1-39.e14. doi:10.1016/j.echo.2014.10.003

Rattka M, Pott A, Kühberger A, Weinmann K, Scharnbeck D, Stephan T, et al. Restoration of sinus rhythm by pulmonary vein isolation improves heart failure with preserved ejection fraction in atrial fibrillation patients. EP Eur. 2020;22(9):1328-1336. doi:10.1093/europace/euaa101

Beukema WP, Elvan A, Sie HT, Ramdat Misier AR, Wellens HJJ. Successful Radiofrequency Ablation in Patients With Previous Atrial Fibrillation Results in a Significant Decrease in Left Atrial Size. Circulation. 2005;112(14):2089-2095. doi:10.1161/CIRCULATIONAHA.104.484766

Xintarakou A, Tzeis S, Psarras S, Asvestas D, Vardas P. Atrial fibrosis as a dominant factor for the development of atrial fibrillation: facts and gaps. Eur Eur Pacing Arrhythm Card Electrophysiol J Work Groups Card Pacing Arrhythm Card Cell Electrophysiol Eur Soc Cardiol. 2020;22(3):342-351. doi:10.1093/europace/euaa009

Soulat-Dufour L, Lang S, Addetia K, Ederhy S, Adavane-Scheuble S, Chauvet-Droit M, et al. Restoring Sinus Rhythm Reverses Cardiac Remodeling and Reduces Valvular Regurgitation in Patients With Atrial Fibrillation. J Am Coll Cardiol. 2022;79(10):951-961. doi:10.1016/j.jacc.2021.12.029

Hammond-Haley M, Providência R, Lambiase PD. Temporal pattern/episode duration-based classification of atrial fibrillation as paroxysmal vs. persistent: is it time to develop a more integrated prognostic score to optimize management? EP Eur. 2018;20(FI_3):f288-f298. doi:10.1093/europace/eux178

Chen LY, Chung MK, Allen LA, Ezekowitz M, Furie KL, McCabe P, et al. Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity: A Scientific Statement From the American Heart Association. Circulation. 2018;137(20):e623-e644. doi:10.1161/CIR.0000000000000568

Kochhäuser S, Joza J, Essebag V, Proietti R, Koehler J, Tsang B, et al. The Impact of Duration of Atrial Fibrillation Recurrences on Measures of Health-Related Quality of Life and Symptoms. Pacing Clin Electrophysiol. 2016;39(2):166-172. doi:10.1111/pace.12772

Marincheva G, Iakobishvili Z, Valdman A, Laish-Farkash A. Left Atrial Strain: Clinical Use and Future Applications—A Focused Review Article. Rev Cardiovasc Med. 2022;23(5):154. doi:10.31083/j.rcm2305154

Ma XX, Boldt LH, Zhang YL, Zhu MR, Hu B, Parwani A, et al. Clinical Relevance of Left Atrial Strain to Predict Recurrence of Atrial Fibrillation after Catheter Ablation: A Meta-Analysis. Echocardiogr Mt Kisco N. 2016;33(5):724-733. doi:10.1111/echo.13184

Hwang HJ, Choi EY, Rhee SJ, Joung B, Lee BH, Lee SH, et al. Left atrial strain as predictor of successful outcomes in catheter ablation for atrial fibrillation: a two-dimensional myocardial imaging study. J Interv Card Electrophysiol Int J Arrhythm Pacing. 2009;26(2):127-132. doi:10.1007/s10840-009-9410-y

Hopman LHGA, Mulder MJ, van der Laan AM, Bhagirath P, Demirkiran A, von Bartheld MB, et al. Left atrial strain is associated with arrhythmia recurrence after atrial fibrillation ablation: Cardiac magnetic resonance rapid strain vs. feature tracking strain. Int J Cardiol. 2023;378:23-31. doi:10.1016/j.ijcard.2023.02.019

Published

2025-06-21

How to Cite

Cañedo Guerra, E., Cabello Ganem, A., Antonio Villa, N. E., Luna Alcala, S., Ana Bayona, M. J., Martínez Domínguez, P., Serrano Román, J., Cruz Aragón, G., Levinstein Jacinto, M., Nava Townsend, S., Rosas, E. A., & Espinola Zavaleta, N. (2025). Impact of pulmonary vein isolation on left atrial contractile function in patients with paroxysmal atrial fibrillation: a prospective cohort analysis using strain echocardiography. Basic Health Sciencies Journal, 3(2), 1–13. https://doi.org/10.24054/cbs.v3i2.4043

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Research Articles

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